Introduction of NMN (β-Nicotinamide Mononucleotide)
β-Nicotinamide Mononucleotide (NMN) is a naturally occurring nucleotide derived from ribose and nicotinamide. It is the direct precursor of NAD+ (Nicotinamide Adenine Dinucleotide), an essential coenzyme found in every living cell. Our NMN is produced via enzymatic biocatalysis technologyusing food-grade starting materials (nicotinamide riboside chloride and ATP/AMP), followed by multi-stage crystallization and desalting purification. The final product achieves ≥99.0% purity (HPLC) with strict control of nicotinamide, nicotinic acid, and solvent residues, fully compliant with international pharmaceutical, nutraceutical, and cosmetic standards.
Differentiated advantages: Unlike traditional chemical synthesis methods which risk residual organic solvents and β/α isomer impurities, our enzyme-catalyzed process produces exclusively the biologically active β-anomer with >99.9% stereoisomeric purity. Compared to nicotinamide riboside (NR), NMN has a phosphate group that allows it to enter cells via specific NMN transporters (Slc12a8), providing more direct and sustained NAD+ elevation. Our enzymatic green process uses no toxic solvents (no DMSO, ethyl acetate, or dichloromethane) and generates minimal waste, ensuring a clean, safe, and highly bioactive product.
Key Active Compounds
The core active compound is β-Nicotinamide Mononucleotide (β-NMN) (CAS: 1094-61-7), chemically described as 3-(aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium inner salt (C₁₁H₁₅N₂O₈P, molecular weight 334.22). As the direct precursor to NAD+ biosynthesis via the salvage pathway, NMN is one to two enzymatic steps from NAD+. With ≥99.0% purity (HPLC), residual nicotinamide <0.1%, nicotinic acid <0.05%, and heavy metals <10 ppm, our NMN ensures maximum safety, stability, and biological conversion efficiency.
Benefits
NAD+ Boosting & skin wellness support: Directly elevates intracellular NAD+ levels, restoring NAD+ to youthful levels. Activates sirtuins (SIRT1–SIRT7), improves mitochondrial function, enhances DNA repair via PARP enzymes, and slows biological aging at the cellular level.
Cognitive & Neuroprotection: NMN crosses the blood-brain barrier (indirectly via Slc12a8 transporters and dephosphorylation/rephosphorylation). Increases NAD+ in brain tissue, improves cerebral blood flow, reduces neuroinflammation, protects against cognitive support, and supports memory formation. Shows potential for Alzheimer’s, cognitive support��s, .
Metabolic Health & Weight Management: Improves insulin sensitivity, enhances glucose homeostasis, reduces hepatic steatosis (fatty liver), lowers LDL cholesterol and triglycerides. Activates AMPK pathway, promotes healthy fat metabolism and prevents diet-induced weight gain.
Cardiovascular Protection: Improves endothelial function, increases vascular elasticity, reduces oxidative stress in heart tissue, protects against ischemia-reperfusion injury, and normalizes blood pressure in age-related vascular dysfunction.
Muscle Function & Physical Performance: Enhances mitochondrial biogenesis in skeletal muscle, improves endurance and exercise capacity, accelerates muscle recovery, reduces fatigue, and counteracts age-related sarcopenia (muscle loss).
DNA Repair & Longevity: PARP enzymes (Poly-ADP-ribose polymerases) consume NAD+ for DNA damage repair. By restoring NAD+, NMN promotes efficient repair of single and double-strand breaks, reducing genomic instability—a hallmark of aging.
Reproductive Health: Improves oocyte quality and quantity in females; supports spermatogenesis in males; protects against age-related fertility decline.
Typical Specification Sheet
| Item | Specification | Test Method |
|---|---|---|
| Product Name | β-Nicotinamide Mononucleotide (β-NMN) | Visual / TLC |
| Active Component | β-NMN ≥99.0% | HPLC (USP method) |
| CAS Number | 1094-61-7 | Chemical Analysis |
| Molecular Formula | C₁₁H₁₅N₂O₈P | Chemical Analysis |
| Molecular Weight | 334.22 | Chemical Calculation |
| Appearance | White to off-white crystalline powder | Visual & Organoleptic |
| Identification (IR) | Conforms to reference standard | FT-IR |
| Specific Rotation [α]₂₀/D | +19.0° to +23.0° (c=1 in H₂O) | Polarimeter |
| pH (1% in water) | 2.5 – 4.0 | pH Meter |
| Water Content (KF) | ≤1.0% | Karl Fischer |
| Purity (HPLC) | ≥99.0% (β-anomer >99.9% of total NMN) | HPLC-DAD |
| Related Substances | Nicotinamide ≤0.15%, Nicotinic acid ≤0.10%, Other impurities ≤0.20% | HPLC |
| Residual Solvents (EtOH, MeOH) | ≤500 ppm | GC |
| Heavy Metals | ≤10 ppm (Pb ≤0.5 ppm, As ≤0.5 ppm, Cd ≤0.5 ppm, Hg ≤0.1 ppm) | ICP-MS |
| Total Plate Count | ≤100 CFU/g | USP <61> |
| Yeast & Mold | ≤50 CFU/g | USP <61> |
| E. coli / Salmonella | Negative | USP <62> |
| Storage | Cool, dry, airtight, inert atmosphere, 2-8°C recommended | N/A |
| Shelf Life | 24 months from date of manufacture (proper storage) | Stability Study |
Application Cases
Pharmaceutical Field: research-grade material for research on healthy aging (NMN has GRAS status in the US and is being studied for Alzheimer’s, metabolic wellness, and heart failure). Used in compounding pharmacies for personalized skin wellness support protocols.
Dietary Supplement Field: Premium ingredient in skin wellness support capsules, liposomal NMN powders, sublingual tablets, and NAD+ boost complex formulations (often combined with resveratrol, TMG, and pterostilbene). Exported to over 40 countries including USA, Japan (where NMN is approved as a functional food ingredient), EU, Australia, and South Korea.
Cosmetics Field: Added to advanced skin wellness support serums, night repair creams, and eye contour treatments. Promotes mitochondrial health in skin cells, reduces photoaging, brightens complexion, and improves barrier function.
Sports Nutrition Field: Used in endurance formulas, recovery powders, and “healthy aging” sports blends for masters athletes. Enhances VO₂ max improvement and reduces exercise-induced oxidative stress.
Why Choose Us
Controllable Raw Materials: Starting materials (nicotinamide riboside chloride) sourced from qualified GMP-grade suppliers with full traceability. All raw materials tested for purity, residual solvents, and heavy metals before production.
Advanced Enzymatic Technology: Proprietary immobilized enzyme biocatalysis process with engineered NMN synthetase. One-step enzymatic conversion from nicotinamide riboside → NMN. No toxic solvents, no isomerization, no heavy metal catalysts. Achieves >99.0% purity with nicotinamide <0.1% (critical for safety, as excess nicotinamide can inhibit sirtuins).
Strict Quality Control: cGMP-compliant facility (ISO 8 cleanroom). Every batch undergoes full HPLC purity, residual nicotinamide/nicotinic acid, residual solvents, heavy metals (ICP-MS), and microbial testing. Third-party validated (Eurofins, SGS) upon request. Stability data supports 24-month shelf life.
Regulatory Compliance: Manufactured under strict ICH Q7 guidelines. Complete documentation package: COA, MSDS, stability study, method validation, allergen statement, Non-GMO, Kosher, Halal, TSE/BSE-free. Support for NDI (New Dietary Ingredient) filing.
Rich Export Experience: Over 8 years of exporting NMN to global markets. Experienced with customs HS code classification (2934.99), US FDA import alerts, and EU REACH/Novel Food compliance. Reliable logistics with temperature-controlled shipping for bulk powders.
Professional Service & Competitive Pricing: In-house analytical chemists and regulatory experts offering custom particle size, encapsulation blends, and stability testing support. Vertical integration from biocatalysis to crystallization eliminates intermediaries, providing pharmaceutical-grade NMN at nutraceutical-friendly pricing. 24-hour technical and after-sales support.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
